1,4-Dioxane

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1,4-Dioxane is a manufacturing by-product of the ethoxylation process. Ethoxylation is a chemical process in which ethylene oxide is added to fatty acids in order to make them more soluble in water. This process makes surfactant agents such as sodium lauryl sulfate less abrasive and gives products enhanced foaming properties.. Unless removed under precise conditions, small amounts of dioxane are produced during ethoxylation. It is found in household products such as detergents, shampoos, body lotions, dishwashing soap, pharmaceuticals and cosmetics.  And, is considered an un-wanted by-product of ethoxylated raw materials resulting from  the ethoxalation process.   The U.S. Food and Drug Administration (FDA) has provided guidance to manufacturers about a process called “vacuum stripping” to help minimize the amount of 1,4-dioxane in their final product. Manufacturers of detergents, shampoos, body lotions, dishwashing soap, pharmaceuticals and cosmetics employing ethoxylated raw materials should conduct laboratory analysis to determine the levels of 1,4- dioxane in their products.

Quantex has  been performing testing for 1,4-Dioxane since our founding in 1992. We use  methodology that employs heated headspace  followed by GC/MS in the SIMS mode. . Quantitation is performed using isotopic dilution GC/MS with 1,4-dioxane-d8 as the isotopic analog.